Sensors & Transducers Journal
(ISSN 1726- 5479)
Vol. 76, Issue 2, February 2007, pp. 945-968
Advances in Biosensing Methods
Reema Taneja, Kennon C. Shelton, Raymond Carlisle, Ajit Sadana
Chemical Engineering Department, University of Mississippi,
University, MS 38677-1848, USA
Phone: (662) 915-5349, fax: (662) 915-7023
Received: 31 January 2007 / Accepted: 22 February 2007 / Published: 26 February 2007
Abstract: A fractal analysis is presented for the binding and dissociation (if applicable) kinetics of analyte-receptor reactions occurring on biosensor surfaces. The applications of the biosensors have appeared in the recent literature. The examples provided together provide the reader with a perspective of the advances in biosensors that are being used to detect analytes of interest. This should also stimulate interest in applying biosensors to other areas of application.
The fractal analysis limits the evaluation of the rate constants for binding and dissociation (if applicable) for the analyte-receptor reactions occurring in biosensor surfaces. The fractal dimension provides a quantitative measure of the degree of heterogeneity on the biosensor surface. Predictive relations are presented that relate the binding co-efficient with the degree of heterogeneity or the fractal dimension on the biosensor surface
Keywords: Biosensors, advances, fractal kinetics, binding, dissociation
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