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Vol. 76, Issue 2, February 2007, pp. 969-977




Interface Layering Phenomena in Capacitance Detection of DNA with Biochips


Sandro Carraraa*, Frank K. Gürkaynakb, Carlotta Guiduccic, Claudio Stagnic, Luca Beninic, Yusuf Leblebicib, Bruno Samorìa, Giovanni De Michelib

aBiochemistry Department, University of Bologna, Bologna, Italy

bEcole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

c DEIS Department, University of Bologna, Bologna, Italy

*Via Irnerio, 48 - 40126 Bologna, Phone.+39 0512094388, E-mail: sandro.carrara@unibo.it



Received: 2 February 2007 / Accepted: 22 February 2007 / Published: 26 February 2007


Abstract: Reliable DNA detection is of great importance for the development of the Lab-on-chip technology. The effort of the most recent projects on this field is to integrate all necessary operations, such as sample preparation (mixing, PCR amplification) together with the sensor user for DNA detection. Among the different ways to sense the DNA hybridization, fluorescence based detection has been favored by the market. However, fluorescence based approaches require that the DNA targets are labeled by means of chromophores. As an alternative label-free DNA detection method, capacitance detection was recently proposed by different authors. While this effect has been successfully demonstrated by several groups, the model used for data analysis is far too simple to describe the real behavior of a DNA sensor. The aim of the present paper is to propose a different electrochemical model to describe DNA capacitance detection.


Keywords: DNA Biochip, capacitance detection, ion layering, constant phase elements


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