bullet Sensors & Transducers Journal

    (ISSN 1726- 5479)


2007 e-Impact Factor


25 Top Downloaded Articles

Journal Subscription 2008

Editorial Calendar 2008

Submit an Article

Editorial Board

Current Issue

Sensors and Transducers Journal's cover


Sensors & Transducers Journal 2007

2000-2002 S&T e-Digest Contents

2003 S&T e-Digest Contents

2004 S&T e-Digest Contents

2005 S&T e-Digest Contents

2006 S&T e-Digest Contents


Best Articles 2007




Vol. 88, Issue 2, February 2008, pp. 21-30




Development of a Fiber-Optic Capillary Evanescent Wave Surface Plasmon Resonance Biosensor


Brian K. KELLER, Olga SHULGA, Christopher P. PALMER, Michael D. DEGRANDPRE


The University of Montana, Department of Chemistry, 32 Campus Drive, Missoula, MT, 59812, USA
E-mail: wavenumber9@hotmail.com, Michael.DeGrandpre@umontana.edu


Received: 31 January 2008   /Accepted: 22 February 2008   /Published: 26 February 2008


Abstract: Development of a surface plasmon resonance (SPR) FOCap (fiber-optic capillary) sensor for bulk and localized refractive index measurements is reported. The FOCap supports multimode light propagation within the capillary wall. An evanescent field, protruding from the capillary wall and into the core, is attenuated by interacting with the surface plasmon oscillations from gold nanoparticles (AuNPs) that are covalently immobilized within the capillary. The FOCap design allows for long pathlength evanescent sensing. The response of the FOCap SPR sensor to bulk refractive index solutions is tested and the optical properties are discussed. The device may also function as a localized refractive index biosensor. Development of a protein-specific biosensor is ongoing but proof-of-concept is confirmed by a non-specific interaction between fibrinogen and a self-assembled monolayer (SAM) covering the AuNP surface. In the future, the FOCap SPR sensor will be tested for sensitivity with biotin-streptavidin affinity and protein specificity will be demonstrated by antibody/antigen affinity interactions. Ultimately this easy-to-assemble SPR biosensor could be utilized in routine protein assays.


Keywords: fiber-optic capillary, capillary waveguide, surface plasmon resonance, fiber-optic biosensor


 Acrobat reader logo Click <here> or title of paper to download the full pages article (612 K)





1999 - 2008 Copyright , International Frequency Sensor Association (IFSA). All Rights Reserved.

Home - News - Links - Archives - Tools - Standardization - Patents - Marketplace - Projects - Wish List - Subscribe - Search - e-Shop - Membership

 Members Area -Sensors Portal -Training Courses - S&T Digest - For advertisers - Bookstore - Forums - Polls - Sensor Jobs - Site Map