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Vol. 214, Issue 7, July 2017, pp. 34-38

 

Bullet

 

Simultaneous Monitoring of Glucose and Lactate by Self-powered Biosensor
 

Ankit Baingane, Naomi Mburu and Gymama Slaughter

University of Maryland Baltimore County and Bioelectronics Laboratory Department of Computer Science and Electrical Engineering 1000 Hilltop Circle, Baltimore, MD 21250, USA
Tel.: +1 410 455 8483, fax: +1 410 455 3969

E-mail: gslaught@umbc.edu

 

Received: 1 June 2017 /Accepted: 12 July 2017 /Published: 31 July 2017

Digital Sensors and Sensor Sysstems

 

Abstract: A dual self-powered biosensing system integrated with energy amplification circuit is described, for simultaneously monitoring glucose and lactate. The self-powered biosensing system is based on the conventional enzymatic biofuel cell equipped with three 4 mm x 4 mm massively dense mesh network of multi-walled carbon nanotubes (MWCNTs) bioelectrodes in parallel configuration. The bioelectrodes employed pyroquinoline quinone glucose dehydrogenase (PQQ-GDH) as the biocatalyst for the glucose oxidation and D-Lactate dehydrogenase (D-LDH) as the biocatalyst for lactate oxidation. A common laccase modified-MWCNTs bioelectrode served as the cathode for the reduction of molecular oxygen. Two charge pump circuits were coupled with 0.1 mF capacitors functioning as transducers. The advantages of employing capacitors were coupled with the efficient energy amplification of the charge pump circuit to amplify the power output from each of the biofuel and charge/discharge the corresponding capacitor. Under operating conditions, the open circuit voltages and short circuit current densities for 180 mg/dL glucose and 25 mM lactate were 339.2 mV and 228.75 A/cm2 and 370 mV and 66.17 A/cm2, respectively. The responses for glucose and lactate were linear up to 630 mg/dL and 30 mM with sensitivities of 20.11 Hz/ mM cm-2 and 9.869 Hz/ mM cm-2, respectively. The potential of the described system was demonstrated to provide stable voltage and current output that was capable of driving the charge pump circuit integrated with the capacitor for simultaneously monitoring glucose and lactate. These results were in good agreement with those previously reported.

 

Keywords: Glucose, Lactate, Biofuel cell, Voltage boosting, Biosensing.

 

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