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Vol. 28, Special Issue, April-May 2018, pp. 2-6




Transdermal Glucose Monitoring Using Glucose Binding Protein-Based Fiber Optic Biosensor
Coupled with Microneedles

1, 2 Cristina TIANGCO, 3, 4 Abhay ANDAR, 2 Fortunato SEVILLA III, 3, 4 Govind RAO and 1, 2 Leah TOLOSA

1 Department of Chemical Engineering, University of Santo Tomas, Espaňa Boulevard, 1015, Manila, Philippines
2 Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espaňa Boulevard, 1015, Manila, Philippines
3 Center for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore, MD, 21250
4 Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, Baltimore, MD, 21250
1 E-mail: cetiangco@ust.edu.ph


Received: 28 March 2018 /Accepted: 28 May 2018 /Published: 31 May 2018

Digital Sensors and Sensor Sysstems


Abstract: In this study, microneedles were used to facilitate a faster diffusion of transdermal glucose. Microneedles were used in transdermal drug delivery studies. A franz cell with pigskin as a membrane was employed as the main setup for in vitro passive diffusion studies. Real time monitoring of diffusion of transdermal glucose was monitored using a fiber optic biosensor with glucose binding protein immobilized on Nickel-Nitriloacetic acid agarose beads as sensing membrane. Results showed faster diffusion rates with the use of microneedles compared with uncompromised skin and the transdermal glucose concentrations were also increased. This showed that microneedles could be promising tool for noninvasive glucose sensing.


Keywords: Microneedles, Transdermal glucose, Fiber optic biosensor.


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