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Vol. 225, Issue 9, September 2018, pp. 41-48




Sphingolipid Gel/Fluid Phase Transition Measurement by Integrated Resonance Probe Light

1 Qingyue LI, 1 Lucas GARNIER, 1 Véronique VIE, 2 Hervé LHERMITE, 1 Alain MOREAC, 1 Denis MORINEAU,
Claire BOURLIEU-LACANAL, 1 Aziz GHOUFI, 4 Etienne GAVIOT, 1 Eric GICQUEL, 1, * Bruno B?CHE

1 Univ, Rennes, CNRS, IPR (Institut de Physique de Rennes) - UMR 6251, F-35000 Rennes, France
2 Univ, Rennes, CNRS, IETR (Institut d’Electronique et des Técommunications de Rennes) - UMR 6164, F-35000 Rennes, France
3 Univ Montpellier II, INRA CIRAD, IATE, F-334060 Montpellier, France
4 Univ Maine, CNRS, ILAUM (Laboratoire d’Acoustique de l’Université du Maine) - UMR 6613, F-72000 Le Mans, France
Tel.: +33 (0)223235257

E-mail: bruno.beche@univ-rennes1.fr


Received: 25 June 2018 /Accepted: 31 August 2018 /Published: 30 September 2018

Digital Sensors and Sensor Sysstems


Abstract: The paper describes nanophotonic sensors realized by way of inexpensive organic processes. As hybrid silica/polymer resonators, they are suited to detect biological molecules in gel/fluid phase transition at infinitesimal concentrations (sphingomyelin lipids). Such a family of photonic structures is made of specific amplified deep UV210 photoresist-polymer waveguides coupled by a sub-wavelength gap with various racetrack micro-resonators. Thus, temperature dependent wavelength shifts characterizing the optical resonances of the device have been evaluated, highlighting a low thermal feature of the sensor, which is advantageous for this specific application. With an adapted vesicle lipid deposition process, specific in biology, together with an apt experimental thermo-photonic protocol, the dynamic evolution of the sphingomyelin lipid phase transition has been followed and assessed. The ability to detect their gel/fluid transition phase and melting temperature has been demonstrated with a mass product factor value 107 lower than that of classical methods as differential scanning calorimetry. The global equilibrium regimes of the coupling effect of resonances and the scattered part of the light are clearly highlighted as markedly modified by the dynamic of the sphingomyelin during its own phase transition.


Keywords: Nanophotonics, Microresonators, Sensors, Polymers, Lipids, Sphingomyelin, Phase transition detection.


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