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Vol. 228, Issue 12, December 2018, pp. 48-62




Nanostructure Protein Toroidal Array Devices Promoted Room Temperature Superconductivity
and Direct Sensing of Collagen-1


1 Advanced Biomimetic Sensors, Inc., 11140 Rockville Pike, Suite 440, Unit 422, Rockville, MD 20852, USA
2 Bruker Nano, 19 Fortune Dr., Billerica, MA 01821, USA
3 Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA
4 University of Maryland Medical System, 22 South Greene St, Baltimore, MD 21201, USA
Tel.: 240-706-5687, fax: 240-630-4051

E-mail: ellenchen@nanobiomimeticsensors.com


Received: 11 June 2018 /Accepted: 1 October 2018 /Published: 31 December 2018

Digital Sensors and Sensor Sysstems


Abstract: Two types of superconductive/memristive devices were developed based on a protein Matrix Matelloproteinase-2 (MMP) cross-linked polymer toroidal membrane and a biomimetic multiple-layered super lattice organo-metalic membrane. Cooper pair’s two-wave sounds were “heard” in the Josephson toroidal junction using the Open Circuit Potential method. The rate constant for the exponential voltage decay curve of the innate protein device is 122-fold higher than that of the biomimetic device. Sine wave phase change and oscillating curves were observed at 1 and 10 kHz for multiple scan cycles, with peak intensity kept constant on the innate protein device compared with the biomimetic device. The quantum conductance density of the biomimetic device is 3.1´1010-fold higher than the activated protein device at 1 Hz. The protein devices were able to direct detect collagen -1 at the innate and activated state. The biomimetic device has a wider analytical range and higher sensitivity compared with the protein device.


Keywords: Protein Made Nanostructure Toroidal Circular-accelerator Array; High Frequency Innate Protein Oscillator and Superconductor; Room Temperature Organo-metal superconductor; Nanobiomimetic MMP-2 Superconductor; Superlattice; Josephson Junction; Superconducting and Sensing Device; Probe-free and Label-free.


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