Vol. 92, Issue 5, May 2008, pp. 122-133

Recent Advances in DNA Biosensor

Suman and Ashok Kumar*

Department of Material and Devices, Institute of Advance Research and Studies, Amity University, Noida, India, 201303

^*Institute of Genomics and Integrative Biology, Mall Road, Delhi, India, 110007

Tel: +91 11 27666156, E-mail: ashokigib@rediffmail.com

Received: 21 March 2008   /Accepted: 20 May 2008   /Published: 26 May 2008

Abstract: DNA based biosensors have recently gained much importance for detection of target genes responsible for diseases, in food industry, environment and in agriculture. This article describes different types of DNA based biosensors, their advantages and basic principle of operating system. The DNA biosensors provide fast, simple, economical, sensitive and selective detection of target genes by hybridization with specific probe. Various new strategies for DNA based biosensors have described along with recent trends and challenges in development of technology. Electrochemical biosensor has more advantages due to electrochemical behaviour of the labels towards the hybridization reaction on electrode surface or in solution in the presence of redox indicators. PCR free DNA biochip is emerging new tools in the field of diagnosis.

Keywords: DNA biosensors, Optical, Electrochemical, Piezoelectric, Biochip

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