Abstract: Topological superconductive and memristive nanostructured toroidal-tower array device systems are reported for direct electrochemical sensing of multiple biomarkers based on the biomimetic glucose…pyruvate…acetyl CoA (ACoA) fuel energy pathway of a mitochondria cell. The device comprises flexible fractional Josephson junctions (FFJJ) made of innate matrix metalloproteinase (MMP)-2 cross- linked with conductive polymers forming a first layer membrane on the electrode surface, a medium comprising of glucose and acetyl CoA (ACoA) molecules (as the GA medium), serves as an insulator or a conductor when pyruvate molecules activated the medium, and the second layer comprising of an innate Heat Shock Protein (HSP) cross- linked with the similar polymers on top of the first layer. Cooper-pairs reentry between the state of superconductivity at room temperature and the memristive state are enabled through a molecular “Valve” GA medium activated by a biomarker to switch the electron move in a 3D horizontal-vertical pathway from low Josephson frequency to high Josephson frequency, enabled the device to direct sensitive and quantitative sensing multiple-biomarkers without antibody or labeling, wherein potential applications are discussed.

Keywords: Protein–Protein Interaction Network Sensor (PPINS), Double-layer Superlattice Membrane, Multiple-Biomarker, Quantum Conductance, Flexible Fractional Josephson junction, Friedel-oscillation, 3D Cooper-pair Switch

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