Sensors & Transducers



Vol. 253, Issue 6, November 2021, pp. 1-8





Basic Research on Blood Coagulation Measurement of Extracorporeal Circulation Circuit Using Photoacoustic Imaging of LED Light Source



1, * Takahiro Wabe, 2, 3 Ryo Suzuki, 4 Akimitsu Fujii, 5 Yohsuke Uchida,

2, 3 Kazuo Maruyama and 1 Yasutaka Uchida



1 Teikyo University of Science, Department of Life & Health Sciences, Faculty of Life & Environmental Sciences, 2-2-1 Senjyusakuragi, Adachi-ku, Tokyo, Japan

2 Faculty of Pharma-Science, Teikyo University, Tokyo, Japan

3 Advanced Comprehensive Research Organization (ACRO), Teikyo University, Tokyo, Japan

4 Tokyo College of Medico-Pharmaco Technology, Tokyo, Japan 5 Shuto iko,
Tokyo, Japan

1 Tel.: 8169101010, fax: + 8169103800

* E-mail: takahiro091@gmail.com



Received: 25 October 2021 /Accepted: 27 November 2021 /Published: 30 November 2021





Abstract: In extracorporeal circulation devices such as ECMO, blood coagulation occurs due to various factors. Blood coagulation in the extracorporeal circulation circuit is detected ex post facto by existing pressure sensors. Subsequent detection of blood clots leads to the destruction of blood in the circuit, which is detrimental to the patient. Therefore, for the purpose of preliminary measurement in the extracorporeal circulation circuit, we will conduct basic research on measurement using photoacoustic imaging using LEDs as a light source and report it (AcousticX). As a result of measuring the blood in the extracorporeal circulation circuit circulated using the extracorporeal circulation device by photoacoustic imaging over time, it was found that the wave number and intensity of the photoacoustic wave increased with the passage of time. It has been shown that it is possible to measure the temporal change of blood coagulation circulating in the circuit.


Keywords: Blood coagulation, Photoacoustic imaging, LED, Circuit in an extracorporeal device, Temporal observation, Predictive maintenance.

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