Measurement Site Selection and Validation in Extracorporeal Circuit for Predictive Maintenance of Blood Coagulation using Photoacoustic Imaging of LED Light Source

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Vol. 259, Issue 5, October 2022, pp. 45-51

Measurement Site Selection and Validation in Extracorporeal Circuit for Predictive Maintenance
of Blood Coagulation using Photoacoustic Imaging of LED Light Source

¹ Takahiro Wabe, ^2,3 Ryo Suzuki, ⁴ Akimitsu Fujii, ⁵ Yohsuke Uchida, ^2,3 Kazuo Maruyama and ¹ Yasutaka Uchida

¹ Teikyo University of Science, Department of Life & Health Sciences, Faculty of Life & Environmental Sciences, 2-2-1 Senjyusakuragi, Adachi-ku, Tokyo, Japan
² Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan
³ Advanced Comprehensive Research Organization (ACRO),Teikyo University, 2-21-1 Kaga, Itabashi-ku, Tokyo, Japan
⁴ Tokyo college of Medico-Pharmaco Technology, 2-11-1 Higashikasai, Edogawa-ku, Tokyo, Japan
⁵ Shuto iko, 1-7-3 Nishisinjuku, Sinnjuku-ku, Tokyo, Japan
Tel.: + 8169101010, fax: + 8169103800

E-mail: takahiro091@gmail.com

Received: 5 September 2022 /Accepted: 7 October 2022 /Published: 31 October 2022

Abstract: Blood purification therapy that removes pathogenic substances and unnecessary blood components in blood is performed by extracorporeal circulation therapy that draws blood out of the body. In extracorporeal circulation therapy, blood is filled in the circuit and circulated outside the body by a pump, but the blood coagulates due to a foreign body reaction in the circuit. Anticoagulants such as heparin are used as blood coagulation measures, but they are not absolute. There is a need for a measurement method that can be predicted before blood coagulation. Photoacoustic imaging was used for predictive maintenance measurements. In photoacoustic imaging used for extracorporeal circulation therapy, the amount of data used must be reduced because it is constantly measured. Accordingly, in this study, we identified areas where photoacoustic imaging changes significantly over time due to blood coagulation, and reduced the volume of data by limiting the area to be measured to 233 pixels where 218240 pixels are normally required for measurement. In addition, because we were able to identify the measurement site, based on that, we develop a predictive maintenance system based on changes in blood coagulation over time in an extracorporeal blood circulation circuit that simulates the environment of extracorporeal blood circulation therapy.

Keywords: Blood coagulation, Photoacoustic imaging, LED, Extracorporeal circulation therapy, Predictive maintenance.

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